Pregnancy prevention practices among women with multiple partners in an HIV prevention trial
Identifieur interne : 000D36 ( Main/Exploration ); précédent : 000D35; suivant : 000D37Pregnancy prevention practices among women with multiple partners in an HIV prevention trial
Auteurs : Kathleen M. Macqueen [États-Unis] ; Laura Johnson [États-Unis] ; Patty Alleman [États-Unis] ; Betty Akumatey [Ghana] ; Taiwo Lawoyin [Nigeria] ; Tiburce Nyiama [Cameroun]Source :
- Journal of acquired immune deficiency syndromes : (1999) [ 1525-4135 ] ; 2007.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adénine (analogues et dérivés), Adénine (usage thérapeutique), Agents antiVIH (usage thérapeutique), Comportement en matière de contraception (), Comportement en matière de santé, Contraceptifs féminins, Contraception (), Entretiens comme sujet, Femelle, Grossesse, Humains, Infections à VIH (), Phosphonates (usage thérapeutique), Prostitution, Préservatifs masculins (utilisation), Ténofovir.
- MESH :
- analogues et dérivés : Adénine.
- usage thérapeutique : Adénine, Agents antiVIH, Phosphonates.
- utilisation : Préservatifs masculins.
- Pascal (Inist)
- Adolescent, Adulte, Comportement en matière de contraception, Comportement en matière de santé, Contraceptifs féminins, Contraception, Entretiens comme sujet, Femelle, Grossesse, Homme, Humains, Infections à VIH, Prostitution, Ténofovir, Virus immunodéficience humaine, Prévention, Femelle, Condom, Comportement sexuel, Contraception, Microbiologie, Virologie.
- Wicri :
- topic : Homme, Contraception.
English descriptors
- KwdEn :
- Adenine (analogs & derivatives), Adenine (therapeutic use), Adolescent, Adult, Anti-HIV Agents (therapeutic use), Condom, Condoms (utilization), Contraception, Contraception (statistics & numerical data), Contraception Behavior (statistics & numerical data), Contraceptive Agents, Female, Female, HIV Infections (prevention & control), Health Behavior, Human, Human immunodeficiency virus, Humans, Interviews as Topic, Microbiology, Organophosphonates (therapeutic use), Pregnancy, Prevention, Sex Work, Sexual behavior, Tenofovir, Virology.
- MESH :
- chemical , analogs & derivatives : Adenine.
- chemical , therapeutic use : Adenine, Anti-HIV Agents, Organophosphonates.
- prevention & control : HIV Infections.
- statistics & numerical data : Contraception, Contraception Behavior.
- utilization : Condoms.
- Adolescent, Adult, Contraceptive Agents, Female, Female, Health Behavior, Humans, Interviews as Topic, Pregnancy, Sex Work, Tenofovir.
Abstract
Background: Women enrolled in microbicide and pre-exposure prophylaxis (PrEP) HIV prevention trials are not allowed to continue use of study products when pregnant because of fetal safety concerns. High pregnancy rates among women in trials can undermine statistical measures of safety and effectiveness. Methods: Women enrolled in a PrEP trial in Ghana, Nigeria, and Cameroon had an overall pregnancy rate of 52 per 100 person-years of observation. In-depth interviews were conducted with 67 women who were asked to describe any changes made in their pregnancy prevention practices after enrolling in the trial. Results: Most women (n = 44, 65%) reported changing pregnancy prevention practices after enrolling in the trial. Twice as many reported using condoms for pregnancy prevention after enrollment (n = 56, 84%) than before (n = 27, 40%). Cluster analysis identified site-specific patterns. Nigerian women tended to report using condoms for dual protection before and after trial enrollment. Cameroonian women tended to rely on natural methods before and after trial enrollment. Ghanaian women tended to switch from hormonal methods to condoms. Conclusions: The role of condoms in HIV prevention trials must not be diminished. Their use-effectiveness for contraception is likely too low for microbicide and PrEP trial needs, however. HIV prevention trials with women should be appropriately staffed to provide effective contraceptive counseling and, if needed, direct provision of contraceptives. This must be done without undermining women's reproductive rights.
Affiliations:
- Cameroun, Ghana, Nigeria, États-Unis
- Caroline du Nord, Région du Grand Accra
- Accra, Legon (Ghana)
- Université du Ghana
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Le document en format XML
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Macqueen</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Family Health International</s1><s2>Research Triangle Park, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Johnson, Laura" sort="Johnson, Laura" uniqKey="Johnson L" first="Laura" last="Johnson">Laura Johnson</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Family Health International</s1><s2>Research Triangle Park, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Alleman, Patty" sort="Alleman, Patty" uniqKey="Alleman P" first="Patty" last="Alleman">Patty Alleman</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Family Health International</s1><s2>Research Triangle Park, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Akumatey, Betty" sort="Akumatey, Betty" uniqKey="Akumatey B" first="Betty" last="Akumatey">Betty Akumatey</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>University of Ghana</s1><s2>Legon</s2><s3>GHA</s3><sZ>4 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><settlement type="town">Legon (Ghana)</settlement><region type="region">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Lawoyin, Taiwo" sort="Lawoyin, Taiwo" uniqKey="Lawoyin T" first="Taiwo" last="Lawoyin">Taiwo Lawoyin</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University College Hospital</s1><s2>Ibadan</s2><s3>NGA</s3><sZ>5 aut.</sZ></inist:fA14><country>Nigeria</country><wicri:noRegion>University College Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Nyiama, Tiburce" sort="Nyiama, Tiburce" uniqKey="Nyiama T" first="Tiburce" last="Nyiama">Tiburce Nyiama</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute for Research, Socioeconomic Development, and Communication</s1><s2>Yaounde</s2><s3>CMR</s3><sZ>6 aut.</sZ></inist:fA14><country>Cameroun</country><wicri:noRegion>Yaounde</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of acquired immune deficiency syndromes : (1999)</title><title level="j" type="abbreviated">J. acquir. immune defic. syndr. : (1999)</title><idno type="ISSN">1525-4135</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of acquired immune deficiency syndromes : (1999)</title><title level="j" type="abbreviated">J. acquir. immune defic. syndr. : (1999)</title><idno type="ISSN">1525-4135</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenine (analogs & derivatives)</term><term>Adenine (therapeutic use)</term><term>Adolescent</term><term>Adult</term><term>Anti-HIV Agents (therapeutic use)</term><term>Condom</term><term>Condoms (utilization)</term><term>Contraception</term><term>Contraception (statistics & numerical data)</term><term>Contraception Behavior (statistics & numerical data)</term><term>Contraceptive Agents, Female</term><term>Female</term><term>HIV Infections (prevention & control)</term><term>Health Behavior</term><term>Human</term><term>Human immunodeficiency virus</term><term>Humans</term><term>Interviews as Topic</term><term>Microbiology</term><term>Organophosphonates (therapeutic use)</term><term>Pregnancy</term><term>Prevention</term><term>Sex Work</term><term>Sexual behavior</term><term>Tenofovir</term><term>Virology</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adénine (analogues et dérivés)</term><term>Adénine (usage thérapeutique)</term><term>Agents antiVIH (usage thérapeutique)</term><term>Comportement en matière de contraception ()</term><term>Comportement en matière de santé</term><term>Contraceptifs féminins</term><term>Contraception ()</term><term>Entretiens comme sujet</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Infections à VIH ()</term><term>Phosphonates (usage thérapeutique)</term><term>Prostitution</term><term>Préservatifs masculins (utilisation)</term><term>Ténofovir</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adenine</term><term>Anti-HIV Agents</term><term>Organophosphonates</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adénine</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Contraception</term><term>Contraception Behavior</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Adénine</term><term>Agents antiVIH</term><term>Phosphonates</term></keywords><keywords scheme="MESH" qualifier="utilisation" xml:lang="fr"><term>Préservatifs masculins</term></keywords><keywords scheme="MESH" qualifier="utilization" xml:lang="en"><term>Condoms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Contraceptive Agents, Female</term><term>Female</term><term>Health Behavior</term><term>Humans</term><term>Interviews as Topic</term><term>Pregnancy</term><term>Sex Work</term><term>Tenofovir</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Comportement en matière de contraception</term><term>Comportement en matière de santé</term><term>Contraceptifs féminins</term><term>Contraception</term><term>Entretiens comme sujet</term><term>Femelle</term><term>Grossesse</term><term>Homme</term><term>Humains</term><term>Infections à VIH</term><term>Prostitution</term><term>Ténofovir</term><term>Virus immunodéficience humaine</term><term>Prévention</term><term>Femelle</term><term>Condom</term><term>Comportement sexuel</term><term>Contraception</term><term>Microbiologie</term><term>Virologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Contraception</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Women enrolled in microbicide and pre-exposure prophylaxis (PrEP) HIV prevention trials are not allowed to continue use of study products when pregnant because of fetal safety concerns. High pregnancy rates among women in trials can undermine statistical measures of safety and effectiveness. Methods: Women enrolled in a PrEP trial in Ghana, Nigeria, and Cameroon had an overall pregnancy rate of 52 per 100 person-years of observation. In-depth interviews were conducted with 67 women who were asked to describe any changes made in their pregnancy prevention practices after enrolling in the trial. Results: Most women (n = 44, 65%) reported changing pregnancy prevention practices after enrolling in the trial. Twice as many reported using condoms for pregnancy prevention after enrollment (n = 56, 84%) than before (n = 27, 40%). Cluster analysis identified site-specific patterns. Nigerian women tended to report using condoms for dual protection before and after trial enrollment. Cameroonian women tended to rely on natural methods before and after trial enrollment. Ghanaian women tended to switch from hormonal methods to condoms. Conclusions: The role of condoms in HIV prevention trials must not be diminished. Their use-effectiveness for contraception is likely too low for microbicide and PrEP trial needs, however. HIV prevention trials with women should be appropriately staffed to provide effective contraceptive counseling and, if needed, direct provision of contraceptives. This must be done without undermining women's reproductive rights.</div></front></TEI><affiliations><list><country><li>Cameroun</li><li>Ghana</li><li>Nigeria</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Région du Grand Accra</li></region><settlement><li>Accra</li><li>Legon (Ghana)</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Macqueen, Kathleen M" sort="Macqueen, Kathleen M" uniqKey="Macqueen K" first="Kathleen M." last="Macqueen">Kathleen M. Macqueen</name></region><name sortKey="Alleman, Patty" sort="Alleman, Patty" uniqKey="Alleman P" first="Patty" last="Alleman">Patty Alleman</name><name sortKey="Johnson, Laura" sort="Johnson, Laura" uniqKey="Johnson L" first="Laura" last="Johnson">Laura Johnson</name></country><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Akumatey, Betty" sort="Akumatey, Betty" uniqKey="Akumatey B" first="Betty" last="Akumatey">Betty Akumatey</name></region></country><country name="Nigeria"><noRegion><name sortKey="Lawoyin, Taiwo" sort="Lawoyin, Taiwo" uniqKey="Lawoyin T" first="Taiwo" last="Lawoyin">Taiwo Lawoyin</name></noRegion></country><country name="Cameroun"><noRegion><name sortKey="Nyiama, Tiburce" sort="Nyiama, Tiburce" uniqKey="Nyiama T" first="Tiburce" last="Nyiama">Tiburce Nyiama</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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